Endocrine-disrupting Potential of Pesticides via Nuclear Receptors and Aryl Hydrocarbon Receptor

Endocrine Disrupting Pesticides

Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator.

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, until now described only in vertebrates, that mediates many of the carcinogenic and teratogenic effects of certain environmental pollutants. Here, we describe orthologs of AHR and its dimerization partner AHR nuclear translocator (ARNT) in the nematode Caenorhabditis elegans, encoded by the genes ahr-1 and aha-1, re...

Binding studies using Pichia pastoris expressed human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins.

The aryl hydrocarbon receptor (AHR) is a transcription factor which activates gene transcription by binding to its corresponding enhancer as the heterodimer, which is consisted of AHR and the aryl hydrocarbon receptor nuclear translocator (ARNT). Human AHR can be rather difficult to study, when compared among the AHR of other species, since it is relatively unstable and less sensitive to some l...

Aryl Hydrocarbon Receptor Activation

Endocrine Disrupting Chemicals: Interaction with Estrogen Receptors and in vitro Assessment of Endocrine Activity Potential

University of Konstanz and for coaching me through the project. Thanks to the Haematox group for the scientific but also personal support: you are not only colleagues but really good friends! Thanks to Dr. Michele Reni for the constant presence, for the optimism and for making endurable the therapy. Finally, this work is dedicated to the most important people in my life: mamma, papa' and Tommaso.